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Yongqing Zhou, Xin Wang, Wei Zhang, Bo Tang, Ping Li
《化学科学与工程前沿(英文)》 2022年 第16卷 第1期 页码 4-33 doi: 10.1007/s11705-021-2041-2
关键词: bioactive molecules fluorescent probes in living cells and in vivo review
Chemical transdifferentiation: closer to regenerative medicine
null
《医学前沿(英文)》 2016年 第10卷 第2期 页码 152-165 doi: 10.1007/s11684-016-0445-z
Cell transdifferentiation, which directly switches one type of differentiated cells into another cell type, is more advantageous than cell reprogramming to generate pluripotent cells and differentiate them into functional cells. This process is crucial in regenerative medicine. However, the cell-converting strategies, which mainly depend on the virus-mediated expression of exogenous genes, have clinical safety concerns. Small molecules with compelling advantages are a potential alternative in manipulating cell fate conversion. In this review, we briefly retrospect the nature of cell transdifferentiation and summarize the current developments in the research of small molecules in promoting cell conversion. Particularly, we focus on the complete chemical compound-induced cell transdifferentiation, which is closer to the clinical translation in cell therapy. Despite these achievements, the mechanisms underpinning chemical transdifferentiation remain largely unknown. More importantly, identifying drugs that induce resident cell conversion in vivo to repair damaged tissue remains to be the end-goal in current regenerative medicine.
关键词: cell therapy cell transdifferentiation chemical compounds small molecules tissue regeneration
Emerging immunological strategies: recent advances and future directions
《医学前沿(英文)》 2021年 第15卷 第6期 页码 805-828 doi: 10.1007/s11684-021-0886-x
关键词: cancer immunotherapy bispecific antibodies small molecules chimeric antigen receptor T therapy cancer vaccines
NADPH oxidase and reactive oxygen species as signaling molecules in carcinogenesis
Gang WANG
《医学前沿(英文)》 2009年 第3卷 第1期 页码 1-7 doi: 10.1007/s11684-009-0018-5
关键词: free radicals tumor phox cell proliferation cancer therapy
Polymorphism of pharmaceutical molecules: perspectives on nucleation
Jie LU, Zhen LI, Xiaolin JIANG,
《化学科学与工程前沿(英文)》 2010年 第4卷 第1期 页码 37-44 doi: 10.1007/s11705-009-0294-2
关键词: development Polymorphism elucidation controversial relationship
A ruptured recurrent small bowel gastrointestinal stromal tumour causing hemoperitoneum
null
《医学前沿(英文)》 2015年 第9卷 第1期 页码 108-111 doi: 10.1007/s11684-014-0344-0
Hemoperitoneum is a rare and potentially life-threatening complication of GIST. We reported a 54-year-old man who developed disseminated intra-abdominal recurrence from a previously resected gastrointestinal stromal tumour (GIST) of the small bowel, and the patient presented with hemoperitoneum. Emergent debulking surgery was performed. A high dose imatinib was prescribed. Despite the presence of residual disease, the patient was well clinically 8 months after the operation. Even though, there is no evidence to support the routine use of debulking surgery in the management of GIST. In our patient, disease progression after second line targeted therapy and the absence of alternative treatment options for spontaneous rupture and hemoperitoneum prompted us to treat the patient aggressively. Resection of the ruptured GIST was carried out for control of bleeding and to prevent recurrent bleeding in this patient with good surgical risks. During the treatment decision-making, the patient’s general condition, the risk of surgery and the extent of dissemination were taken into consideration. In this patient who presented with spontaneous rupture of a small intestinal GIST, the novel use of targeted therapy and aggressive surgical treatment produced reasonably good survival outcome.
关键词: gastrointestinal stromal tumour hemoperitoneum small bowel GIST small bowel neoplasm imatinib
Simulation and experimental improvement on a small-scale Stirling thermo-acoustic engine
Mao CHEN,Yonglin JU
《能源前沿(英文)》 2016年 第10卷 第1期 页码 37-45 doi: 10.1007/s11708-015-0390-6
关键词: thermo-acoustic Stirling engine small-scale simulation experiment
Discovery of small molecule degraders for modulating cell cycle
《医学前沿(英文)》 页码 823-854 doi: 10.1007/s11684-023-1027-5
Fine-tuning cell organelle dynamics during mitosis by small GTPases
《医学前沿(英文)》 2022年 第16卷 第3期 页码 339-357 doi: 10.1007/s11684-022-0926-1
Gut microbiota and its implications in small bowel transplantation
null
《医学前沿(英文)》 2018年 第12卷 第3期 页码 239-248 doi: 10.1007/s11684-018-0617-0
The gut microbiota is mainly composed of a diverse population of commensal bacterial species and plays a pivotal role in the maintenance of intestinal homeostasis, immune modulation and metabolism. The influence of the gut microbiota on solid organ transplantation has recently been recognized. In fact, several studies indicated that acute and chronic allograft rejection in small bowel transplantation (SBT) is closely associated with the alterations in microbial patterns in the gut. In this review, we focused on the recent findings regarding alterations in the microbiota following SBT and the potential roles of these alterations in the development of acute and chronic allograft rejection. We also reviewed important advances with respect to the interplays between the microbiota and host immune systems in SBT. Furthermore, we explored the potential of the gut microbiota as a microbial marker and/or therapeutic target for the predication and intervention of allograft rejection and chronic dysfunction. Given that current research on the gut microbiota has become increasingly sophisticated and comprehensive, large cohort studies employing metagenomic analysis and multivariate linkage should be designed for the characterization of host–microbe interaction and causality between microbiota alterations and clinical outcomes in SBT. The findings are expected to provide valuable insights into the role of gut microbiota in the development of allograft rejection and other transplant-related complications and introduce novel therapeutic targets and treatment approaches in clinical practice.
关键词: gut microbiota small bowel transplantation acute rejection chronic rejection mucosal immunity biomarker microbiota-targeted therapy
null
《医学前沿(英文)》 2013年 第7卷 第2期 页码 157-171 doi: 10.1007/s11684-013-0272-4
Non-small-cell lung cancer (NSCLC) is the most common cause of premature death among the malignant diseases worldwide. The current staging criteria do not fully capture the complexity of this disease. Molecular biology techniques, particularly gene expression microarrays, proteomics, and next-generation sequencing, have recently been developed to facilitate effectively its molecular classification. The underlying etiology, pathogenesis, therapeutics, and prognosis of NSCLC based on an improved molecular classification scheme may promote individualized treatment and improve clinical outcomes. This review focuses on the molecular classification of NSCLC based on gene expression microarray technology reported during the past decade, as well as their applications for improving the diagnosis, staging and treatment of NSCLC, including the discovery of prognostic markers or potential therapeutic targets. We highlight some of the recent studies that may refine the identification of NSCLC subtypes using novel techniques such as epigenetics, proteomics, or deep sequencing.
关键词: non-small-cell lung cancer molecular typing individualized medicine molecular-targeted therapy gene expression profiling
Performance prediction of switched reluctance generator with time average and small signal models
Jyoti KOUJALAGI, B. UMAMAHESWARI, R. ARUMUGAM
《能源前沿(英文)》 2013年 第7卷 第1期 页码 56-68 doi: 10.1007/s11708-012-0216-8
关键词: generator reluctance switching model small signal model time average model
《医学前沿(英文)》 2023年 第17卷 第1期 页码 18-42 doi: 10.1007/s11684-022-0976-4
关键词: non-small cell lung cancer driver mutations treatment strategy resistant mechanism immune-checkpoint inhibitors
《医学前沿(英文)》 2022年 第16卷 第2期 页码 176-184 doi: 10.1007/s11684-021-0885-y
关键词: small noncoding RNAs epigenetic inheritance paternal intergenerational inherence extracellular vesicles
《医学前沿(英文)》 2022年 第16卷 第4期 页码 610-617 doi: 10.1007/s11684-021-0827-8
关键词: bevacizumab elderly patient advanced non-small-cell lung cancer overall survival toxicity
标题 作者 时间 类型 操作
Recent advances in small molecule fluorescent probes for simultaneous imaging of two bioactive molecules
Yongqing Zhou, Xin Wang, Wei Zhang, Bo Tang, Ping Li
期刊论文
Polymorphism of pharmaceutical molecules: perspectives on nucleation
Jie LU, Zhen LI, Xiaolin JIANG,
期刊论文
Simulation and experimental improvement on a small-scale Stirling thermo-acoustic engine
Mao CHEN,Yonglin JU
期刊论文
Molecular classification of non-small-cell lung cancer: diagnosis, individualized treatment, and prognosis
null
期刊论文
Performance prediction of switched reluctance generator with time average and small signal models
Jyoti KOUJALAGI, B. UMAMAHESWARI, R. ARUMUGAM
期刊论文
Treatment of advanced non-small cell lung cancer with driver mutations: current applications and future
期刊论文
Paternal environmental exposure-induced spermatozoal small noncoding RNA alteration meditates the intergenerational
期刊论文